CircRNAs Are Here to Stay: A Perspective on the MLL Recombinome

CircRNAs Are Here to Stay: A Perspective on the MLL Recombinome

Chromosomal translocations harbored by cancer genomes are important oncogenic drivers. In MLL rearranged acute leukemia (MLLre) MLL/KMT2A fuses with over 90 partner genes. Mechanistic studies provided clues of MLL fusion protein leukemogenic potential, but models failed to fully recapitulate the dis...

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Bibliographic Details
Main Authors: Anna Dal Molin, Silvia Bresolin, Enrico Gaffo, Caterina Tretti, Elena Boldrin, Lueder H. Meyer, Paola Guglielmelli, Alessandro M. Vannucchi, Geertruij te Kronnie, Stefania Bortoluzzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Genetics
Subjects:
circRNA
leukemia
MLL rearrangements
fusion-circRNA
translocation breakpoint region
blood cells
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00088/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00088/full

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