PNA Length Restriction of Antibacterial Activity of Peptide-PNA Conjugates in Escherichia coli Through Effects of the Inner Membrane

PNA Length Restriction of Antibacterial Activity of Peptide-PNA Conjugates in Escherichia coli Through Effects of the Inner Membrane

Peptide Nucleic Acid (PNA)-peptide conjugates targeting essential bacterial genes are showing promise as antisense antimicrobials in drug discovery. Optimization has focused on selection of target genes and exact localization around the ribosome binding site, but surprisingly a length optimum around...

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Bibliographic Details
Main Authors: Lise Goltermann, Niloofar Yavari, Meiqin Zhang, Anubrata Ghosal, Peter E. Nielsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Microbiology
Subjects:
antisense antimicrobials
peptide nucleic acid
peptide conjugates
bacterial envelope
Escherichia coli
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01032/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.01032/full

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