Prostanoid EP2 Receptors Are Up-Regulated in Human Pulmonary Arterial Hypertension: A Key Anti-Proliferative Target for Treprostinil in Smooth Muscle Cells

Prostanoid EP2 Receptors Are Up-Regulated in Human Pulmonary Arterial Hypertension: A Key Anti-Proliferative Target for Treprostinil in Smooth Muscle Cells

Prostacyclins are extensively used to treat pulmonary arterial hypertension (PAH), a life-threatening disease involving the progressive thickening of small pulmonary arteries. Although these agents are considered to act therapeutically via the prostanoid IP receptor, treprostinil is the only prostac...

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Bibliographic Details
Main Authors: Jigisha A. Patel, Lei Shen, Susan M. Hall, Chabha Benyahia, Xavier Norel, Robin J. McAnulty, Shahin Moledina, Adam M. Silverstein, Brendan J. Whittle, Lucie H. Clapp
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
prostacyclin
prostaglandin
EP2 receptor
human
treprostinil
selexipag
pulmonary arterial smooth muscle cell proliferation
IP receptor agonists
pulmonary hypertension
Online Access:http://www.mdpi.com/1422-0067/19/8/2372

Internet

http://www.mdpi.com/1422-0067/19/8/2372

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