Graphene oxide exacerbates dextran sodium sulfate-induced colitis via ROS/AMPK/p53 signaling to mediate apoptosis

Graphene oxide exacerbates dextran sodium sulfate-induced colitis via ROS/AMPK/p53 signaling to mediate apoptosis

Abstract Background Graphene oxide (GO), a novel carbon-based nanomaterial, has promising applications in biomedicine. However, it induces potential cytotoxic effects on the gastrointestinal (GI) tract cells, and these effects have been largely uncharacterized. The present study aimed to explore the...

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Bibliographic Details
Main Authors: Siliang Liu, Angao Xu, Yanfei Gao, Yue Xie, Zhipeng Liu, Meiling Sun, Hua Mao, Xinying Wang
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Nanobiotechnology
Subjects:
Graphene oxide
Colitis
Intestinal epithelial cell
Apoptosis
Reactive oxygen species
AMP-activated protein kinase
Online Access:https://doi.org/10.1186/s12951-021-00832-5

Internet

https://doi.org/10.1186/s12951-021-00832-5

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