Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach

Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach

Hepatocyte growth factor (HGF) is secreted as an inactive single-chain HGF (scHGF); however, only proteolytically processed two-chain HGF (tcHGF) can activate the MET receptor. We investigated the localization of tcHGF and activated/phosphorylated MET (pMET) using a tcHGF-specific antibody. In day 1...

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Bibliographic Details
Main Authors: Nawaphat Jangphattananont, Hiroki Sato, Ryu Imamura, Katsuya Sakai, Yumi Terakado, Kazuhiro Murakami, Nick Barker, Hiroko Oshima, Masanobu Oshima, Junichi Takagi, Yukinari Kato, Seiji Yano, Kunio Matsumoto
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
HGF
MET receptor
regeneration
smooth muscle cell
stem cell
Online Access:https://www.mdpi.com/1422-0067/20/12/2955

Internet

https://www.mdpi.com/1422-0067/20/12/2955

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