Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy.

Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy.

An arg120gly (R120G) missense mutation in HSPB5 (alpha-beta-crystallin ), which belongs to the small heat shock protein (HSP) family, causes desmin-related cardiomyopathy (DRM), a muscle disease that is characterized by the formation of inclusion bodies, which can contain pre-amyloid oligomer interm...

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Bibliographic Details
Main Authors: Atsushi Sanbe, Takuya Daicho, Reiko Mizutani, Toshiya Endo, Noriko Miyauchi, Junji Yamauchi, Kouichi Tanonaka, Charles Glabe, Akito Tanoue
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2670514?pdf=render

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http://europepmc.org/articles/PMC2670514?pdf=render

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