Interphase Chromosomes in Replicative Senescence: Chromosome Positioning as a Senescence Biomarker and the Lack of Nuclear Motor-Driven Chromosome Repositioning in Senescent Cells

Interphase Chromosomes in Replicative Senescence: Chromosome Positioning as a Senescence Biomarker and the Lack of Nuclear Motor-Driven Chromosome Repositioning in Senescent Cells

This study demonstrates, and confirms, that chromosome territory positioning is altered in primary senescent human dermal fibroblasts (HDFs). The chromosome territory positioning pattern is very similar to that found in HDFs made quiescent either by serum starvation or confluence; but not completely...

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Bibliographic Details
Main Authors: Ishita S. Mehta, Kumars Riyahi, Rita Torres Pereira, Karen J. Meaburn, Martin Figgitt, Ian R. Kill, Christopher H. Eskiw, Joanna M. Bridger
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
replicative senescence (RS)
genome organisation
nuclear motors
chromatin dynamics
chromosome territories
nuclear myosin 1β
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.640200/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.640200/full

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