Interphase Chromosomes in Replicative Senescence: Chromosome Positioning as a Senescence Biomarker and the Lack of Nuclear Motor-Driven Chromosome Repositioning in Senescent Cells
This study demonstrates, and confirms, that chromosome territory positioning is altered in primary senescent human dermal fibroblasts (HDFs). The chromosome territory positioning pattern is very similar to that found in HDFs made quiescent either by serum starvation or confluence; but not completely...
Main Authors: | Ishita S. Mehta, Kumars Riyahi, Rita Torres Pereira, Karen J. Meaburn, Martin Figgitt, Ian R. Kill, Christopher H. Eskiw, Joanna M. Bridger |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-05-01
|
Series: | Frontiers in Cell and Developmental Biology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.640200/full |
Similar Items
-
Modifications de l'organisation de la chromatine liées à l’entrée en sénescence et son impact sur la réplication du génome
by: Besnard, Emilie
Published: (2010) -
Chromosome–nuclear envelope attachments affect interphase chromosome territories and entanglement
by: Nicholas Allen Kinney, et al.
Published: (2018-01-01) -
Implication des protéines HMGA et HMGA2 dans les changements du programme de réplication au cours de la sénescence cellulaire
by: Kahli, Malik
Published: (2011) -
Nuclear Pore Complexes Cluster in Dysmorphic Nuclei of Normal and Progeria Cells during Replicative Senescence
by: Jennifer M. Röhrl, et al.
Published: (2021-01-01) -
Senescence Meets Dedifferentiation
by: Yemima Givaty Rapp, et al.
Published: (2015-06-01)