Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase δ-extending D-loops

Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase δ-extending D-loops

Synthesis-dependent strand annealing (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an obligatory non-crossover outcome, thus avoiding the potential for chromosomal rearrangements and loss of heterozygosity. Genetic analysis identified the Srs2 helicase as a pri...

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Bibliographic Details
Main Authors: Jie Liu, Christopher Ede, William D Wright, Steven K Gore, Shirin S Jenkins, Bret D Freudenthal, M Todd Washington, Xavier Veaute, Wolf-Dietrich Heyer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-05-01
Series:eLife
Subjects:
genome stability
homologous rcombination
crossover avoidance
DNA helicase
Online Access:https://elifesciences.org/articles/22195

Internet

https://elifesciences.org/articles/22195

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