Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

A critical event in ischemia-based cell death is the opening of the mitochondrial permeability transition pore (MPTP). However, the molecular identity of the components of the MPTP remains unknown. Here, we determined that the Bcl-2 family members Bax and Bak, which are central regulators of apoptot...

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Bibliographic Details
Main Authors: Jason Karch, Jennifer Q Kwong, Adam R Burr, Michelle A Sargent, John W Elrod, Pablo M Peixoto, Sonia Martinez-Caballero, Hanna Osinska, Emily H-Y Cheng, Jeffrey Robbins, Kathleen W Kinnally, Jeffery D Molkentin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-08-01
Series:eLife
Subjects:
cell death
mitochondria
necrosis
Online Access:https://elifesciences.org/articles/00772

Internet

https://elifesciences.org/articles/00772

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