Imputation of the rare HOXB13 G84E mutation and cancer risk in a large population-based cohort.

Imputation of the rare HOXB13 G84E mutation and cancer risk in a large population-based cohort.

An efficient approach to characterizing the disease burden of rare genetic variants is to impute them into large well-phenotyped cohorts with existing genome-wide genotype data using large sequenced referenced panels. The success of this approach hinges on the accuracy of rare variant imputation, wh...

Full description

Bibliographic Details
Main Authors: Thomas J Hoffmann, Lori C Sakoda, Ling Shen, Eric Jorgenson, Laurel A Habel, Jinghua Liu, Mark N Kvale, Maryam M Asgari, Yambazi Banda, Douglas Corley, Lawrence H Kushi, Charles P Quesenberry, Catherine Schaefer, Stephen K Van Den Eeden, Neil Risch, John S Witte
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4309593?pdf=render

Internet

http://europepmc.org/articles/PMC4309593?pdf=render

Similar Items