An Inverse Relationship Between c-Kit/CD117 and mTOR Confers NK Cell Dysregulation Late After Severe Injury

An Inverse Relationship Between c-Kit/CD117 and mTOR Confers NK Cell Dysregulation Late After Severe Injury

Major trauma-induced tissue injury causes a dysregulation of the immune system. Severe systemic inflammation occurs early after the insult. Later on, an enhanced risk for life-threatening opportunistic infections develops that culminates at the end of the first week after trauma. CD56bright Natural...

Full description

Bibliographic Details
Main Authors: Björn Bösken, Monika Hepner-Schefczyk, Sonja Vonderhagen, Marcel Dudda, Stefanie B. Flohé
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
trauma
inflammation
IL-12 receptor
mTOR
functional reprogramming
natural killer cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01200/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01200/full

Similar Items