Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function

Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function

Background: Preadipocyte is closely related to obesity-induced inflammation. The impairment of autophagic flux by defective lysosomal function has been observed in adipose tissue from obese mice. While the fatty acid translocase CD36 is an important immuno-metabolic receptor, it remains unclear whet...

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Bibliographic Details
Main Authors: Xiaoxiao Luo, Yanping Li, Ping Yang, Yao Chen, Li Wei, Ting Yu, Jun Xia, Xiong Z. Ruan, Lei Zhao, Yaxi Chen
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:EBioMedicine
Subjects:
CD36
Preadipocytes
Inflammation
Lysosomal calcium
IP3R1
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420301729

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http://www.sciencedirect.com/science/article/pii/S2352396420301729

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