Study of ICOS gene polymorphisms associations with the risk and clinical course of multiple myeloma
In multiple myeloma (MM) patients, various T-cell abnormalities, such as a marked reduction in the proportions of CD4 and CD8 cells expressing co-stimulatory molecules, signal transduction components, Th1/Th2 imbalance and alterations of regulatory T cells/T helper 17 cells (Treg/Th17 ratio), have b...
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doaj-05e455a8d2b94f47a55577fc76d8bb9b2020-11-24T21:23:14ZengIndex Copernicus International S.A.Postępy Higieny i Medycyny Doświadczalnej0032-54491732-26932019-03-017316517210.5604/01.3001.0013.140801.3001.0013.1408Study of ICOS gene polymorphisms associations with the risk and clinical course of multiple myelomaDariusz Woszczyk0Anna Partyka1Marek Kielbinski2Irena Frydecka3Lidia Karabon4Department of Haematology, State Hospital, Opole, PolandDepartment of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, PolandDepartment and Clinic of Haematology, Blood Neoplasms, and Bone Marrow Transplantation, Wroclaw Medical University, PolandDepartment of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, PolandDepartment of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, PolandIn multiple myeloma (MM) patients, various T-cell abnormalities, such as a marked reduction in the proportions of CD4 and CD8 cells expressing co-stimulatory molecules, signal transduction components, Th1/Th2 imbalance and alterations of regulatory T cells/T helper 17 cells (Treg/Th17 ratio), have been observed. The inducible T-cell co-stimulator (ICOS) has been implicated in the induction and regulation of Th1, Th2, and Treg/Th17 immunity. Therefore, we postulate that variations in ICOS gene might be associated with susceptibility and clinical course of MM. We analyzed ICOSISV1+173T>C (rs10932029), ICOSc.1624C>T (rs10932037), ICOSc.602A>C (rs10183087), ICOSc.1564T>C (rs4404254) and ICOSc.2373G>C (rs4675379) polymorphisms in 205 MM patients and 325 controls with TaqMan® SNP Genotyping Assays. None of the investigated ICOS gene polymorphisms were associated with susceptibility to the disease. However, in a multivariate Cox analysis which included the age of diagnosis, ISS, time to the clinical response to the treatment, gender, immunoglobulin classes, ICOS gene variations, we found that time to the response to treatment, ISS stage 3 and possessing of ICOSc.2373G>C [C+] allele were independently associated with the overall survival (HR: 1.35, 2.86 and 3.77, respectively). Although the result of the present study does not confirm the association of the investigated polymorphisms with risk of MM, they indicated that variations in ICOS gene might influence overall survival. http://phmd.pl/gicid/01.3001.0013.1408ICOSgene polymorphismsMM |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dariusz Woszczyk Anna Partyka Marek Kielbinski Irena Frydecka Lidia Karabon |
spellingShingle |
Dariusz Woszczyk Anna Partyka Marek Kielbinski Irena Frydecka Lidia Karabon Study of ICOS gene polymorphisms associations with the risk and clinical course of multiple myeloma Postępy Higieny i Medycyny Doświadczalnej ICOS gene polymorphisms MM |
author_facet |
Dariusz Woszczyk Anna Partyka Marek Kielbinski Irena Frydecka Lidia Karabon |
author_sort |
Dariusz Woszczyk |
title |
Study of ICOS gene polymorphisms associations with the risk and clinical course of multiple myeloma |
title_short |
Study of ICOS gene polymorphisms associations with the risk and clinical course of multiple myeloma |
title_full |
Study of ICOS gene polymorphisms associations with the risk and clinical course of multiple myeloma |
title_fullStr |
Study of ICOS gene polymorphisms associations with the risk and clinical course of multiple myeloma |
title_full_unstemmed |
Study of ICOS gene polymorphisms associations with the risk and clinical course of multiple myeloma |
title_sort |
study of icos gene polymorphisms associations with the risk and clinical course of multiple myeloma |
publisher |
Index Copernicus International S.A. |
series |
Postępy Higieny i Medycyny Doświadczalnej |
issn |
0032-5449 1732-2693 |
publishDate |
2019-03-01 |
description |
In multiple myeloma (MM) patients, various T-cell abnormalities, such as a marked reduction in the proportions of CD4 and CD8 cells expressing co-stimulatory molecules, signal transduction components, Th1/Th2 imbalance and alterations of regulatory T cells/T helper 17 cells (Treg/Th17 ratio), have been observed. The inducible T-cell co-stimulator (ICOS) has been implicated in the induction and regulation of Th1, Th2, and Treg/Th17 immunity. Therefore, we postulate that variations in ICOS gene might be associated with susceptibility and clinical course of MM. We analyzed ICOSISV1+173T>C (rs10932029), ICOSc.1624C>T (rs10932037), ICOSc.602A>C (rs10183087), ICOSc.1564T>C (rs4404254) and ICOSc.2373G>C (rs4675379) polymorphisms in 205 MM patients and 325 controls with TaqMan® SNP Genotyping Assays.
None of the investigated ICOS gene polymorphisms were associated with susceptibility to the disease. However, in a multivariate Cox analysis which included the age of diagnosis, ISS, time to the clinical response to the treatment, gender, immunoglobulin classes, ICOS gene variations, we found that time to the response to treatment, ISS stage 3 and possessing of ICOSc.2373G>C [C+] allele were independently associated with the overall survival (HR: 1.35, 2.86 and 3.77, respectively).
Although the result of the present study does not confirm the association of the investigated polymorphisms with risk of MM, they indicated that variations in ICOS gene might influence overall survival.
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topic |
ICOS gene polymorphisms MM |
url |
http://phmd.pl/gicid/01.3001.0013.1408 |
work_keys_str_mv |
AT dariuszwoszczyk studyoficosgenepolymorphismsassociationswiththeriskandclinicalcourseofmultiplemyeloma AT annapartyka studyoficosgenepolymorphismsassociationswiththeriskandclinicalcourseofmultiplemyeloma AT marekkielbinski studyoficosgenepolymorphismsassociationswiththeriskandclinicalcourseofmultiplemyeloma AT irenafrydecka studyoficosgenepolymorphismsassociationswiththeriskandclinicalcourseofmultiplemyeloma AT lidiakarabon studyoficosgenepolymorphismsassociationswiththeriskandclinicalcourseofmultiplemyeloma |
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1725992800581844992 |