Y682 mutation of amyloid precursor protein promotes endo-lysosomal dysfunction by disrupting APP-SorLA interaction

Y682 mutation of amyloid precursor protein promotes endo-lysosomal dysfunction by disrupting APP-SorLA interaction

The intracellular transport and localization of amyloid precursor protein (APP) are critical determinants of APP processing and β-amyloid peptide production, thus crucially important for the pathophysiology of Alzheimer’s disease (AD). Notably, the C-terminal Y682ENPTY687 domain of APP binds to spec...

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Bibliographic Details
Main Authors: Luca Rosario La Rosa, Lorena ePerrone, Morten Schallburg Nielsen, Pietro eCalissano, Olav Michael Andersen, Carmela eMatrone
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Lysosomes
Alzheimer’s disease
APP
abeta
endosome
Y682G mutation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00109/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00109/full

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