Prognostic Impact of APOBEC3B Expression in Metastatic Urothelial Carcinoma and Its Association with Tumor-Infiltrating Cytotoxic T Cells

Prognostic Impact of APOBEC3B Expression in Metastatic Urothelial Carcinoma and Its Association with Tumor-Infiltrating Cytotoxic T Cells

APOBEC3B enzymes are endogenous carcinogenic mutagens. Metastatic urothelial carcinomas often harbor APOBEC3B-mediated mutations in which tCw to T or G substitution occurs. Here, we evaluated patient survival and CD8+ T-cell density according to APOBEC3B expression in patients with metastatic urothe...

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Bibliographic Details
Main Authors: Hyunho Kim, Okran Kim, Myung Ah Lee, Ji Youl Lee, Sung-Hoo Hong, U-Syn Ha, Kwangil Yim, In-Ho Kim
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Current Oncology
Subjects:
mutagen
tumor-infiltrating T-lymphocyte
cytotoxic
urologic neoplasm
prognosis
Online Access:https://www.mdpi.com/1718-7729/28/3/154

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https://www.mdpi.com/1718-7729/28/3/154

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