Rapid Generation of Multiple Loci-Engineered Marker-free Poxvirus and Characterization of a Clinical-Grade Oncolytic Vaccinia Virus

Rapid Generation of Multiple Loci-Engineered Marker-free Poxvirus and Characterization of a Clinical-Grade Oncolytic Vaccinia Virus

Recombinant poxviruses, utilized as vaccine vectors and oncolytic viruses, often require manipulation at multiple genetic loci in the viral genome. It is essential for viral vectors to possess no adventitious mutations and no (antibiotic) selection marker in the final product for human patients in o...

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Bibliographic Details
Main Authors: Zong Sheng Guo, Zuqiang Liu, Magesh Sathaiah, Jiahu Wang, Roshni Ravindranathan, Eun Kim, Shaohua Huang, Thomas W. Kenniston, John C. Bell, Herbert J. Zeh, III, Lisa H. Butterfield, Andrea Gambotto, David L. Bartlett
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
vaccinia virus
oncolytic virus
vaccine
cancer
method
marker-free poxvirus
clinical grade
immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117301067

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http://www.sciencedirect.com/science/article/pii/S2329050117301067

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