Transplantable Melanomas in Hamsters and Gerbils as Models for Human Melanoma. Sensitization in Melanoma Radiotherapy—From Animal Models to Clinical Trials

Transplantable Melanomas in Hamsters and Gerbils as Models for Human Melanoma. Sensitization in Melanoma Radiotherapy—From Animal Models to Clinical Trials

The focus of the present review is to investigate the role of melanin in the radioprotection of melanoma and attempts to sensitize tumors to radiation by inhibiting melanogenesis. Early studies showed radical scavenging, oxygen consumption and adsorption as mechanisms of melanin radioprotection. Exp...

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Bibliographic Details
Main Authors: Martyna Śniegocka, Ewa Podgórska, Przemysław M. Płonka, Martyna Elas, Bożena Romanowska-Dixon, Małgorzata Szczygieł, Michał A. Żmijewski, Mirosława Cichorek, Anna Markiewicz, Anna A. Brożyna, Andrzej T. Słominski, Krystyna Urbańska
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:International Journal of Molecular Sciences
Subjects:
melanoma
melanins
Bomirski hamster melanoma
ocular melanoma
human melanoma
X-rays
neutrons
proton beam irradiation
radio-chelation therapy
radio-photo-therapy
chemo-radiotherapy
tumor vessels
Online Access:http://www.mdpi.com/1422-0067/19/4/1048

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http://www.mdpi.com/1422-0067/19/4/1048

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