Aberrant activation of the Hedgehog signalling pathway in squamous cell carcinoma of the vulva as a potential target for cancer therapy

Aberrant activation of the Hedgehog signalling pathway in squamous cell carcinoma of the vulva as a potential target for cancer therapy

Abstract In a previous study, we showed that the Hedgehog (Hh) signalling pathway is aberrantly activated in vulval squamous cell carcinoma (VSCC). In this study, we further validated our findings on a prospective cohort of primary VSCC cases, where immunohistochemical staining confirmed that key Hh...

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Bibliographic Details
Main Authors: Jason K. W. Yap, Khalil Uddin, Rachel Pounds, Danielle O’Neill, Sean Kehoe, Raji Ganesan, Christopher W. Dawson
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-96940-1

Internet

https://doi.org/10.1038/s41598-021-96940-1

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