An evolutionary framework for association testing in resequencing studies.

Sequencing technologies are becoming cheap enough to apply to large numbers of study participants and promise to provide new insights into human phenotypes by bringing to light rare and previously unknown genetic variants. We develop a new framework for the analysis of sequence data that incorporate...

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Bibliographic Details
Main Authors: C Ryan King, Paul J Rathouz, Dan L Nicolae
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2978703?pdf=render