Selection of a Single Domain Antibody, Specific for an HLA-Bound Epitope of the Mycobacterial Ag85B Antigen

Selection of a Single Domain Antibody, Specific for an HLA-Bound Epitope of the Mycobacterial Ag85B Antigen

T cells recognizing epitopes on the surface of mycobacteria-infected macrophages can impart protection, but with associated risk for reactivation to lung pathology. We aimed to identify antibodies specific to such epitopes, which carry potentials for development toward novel therapeutic constructs....

Full description

Bibliographic Details
Main Authors: Paola A. Ortega, Mayra Silva-Miranda, Alfredo Torres-Larios, Eduardo Campos-Chávez, Kees C. L. C. M. Franken, Tom H. M. Ottenhoff, Juraj Ivanyi, Clara Espitia
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
single domain antibodies
peptide-human leukocyte antigen complex
mycobacterial Ag85B
T cell receptor-like antibodies
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.577815/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.577815/full

Similar Items