High Copy-Number Variation Burdens in Cranial Meningiomas From Patients With Diverse Clinical Phenotypes Characterized by Hot Genomic Structure Changes

High Copy-Number Variation Burdens in Cranial Meningiomas From Patients With Diverse Clinical Phenotypes Characterized by Hot Genomic Structure Changes

Meningiomas, as the most common primary tumor of the central nervous system, are known to harbor genomic aberrations that associate with clinical phenotypes. Here we performed genome-wide genotyping for cranial meningiomas in 383 Chinese patients and identified 9,821 copy-number variations (CNVs). P...

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Bibliographic Details
Main Authors: Junpeng Ma, Yaqiang Hong, Wei Chen, Da Li, Kaibing Tian, Ke Wang, Yang Yang, Yuan Zhang, Yujia Chen, Lairong Song, Liangpeng Chen, Liwei Zhang, Jiang Du, Junting Zhang, Zhen Wu, Dake Zhang, Liang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Oncology
Subjects:
copy number variation
female prominence
multiple meningiomas
oncogenic driver
recurrence
tumor location
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01382/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01382/full

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