BubR1 Acts as a Promoter in Cellular Motility of Human Oral Squamous Cancer Cells through Regulating MMP-2 and MMP-9

BubR1 Acts as a Promoter in Cellular Motility of Human Oral Squamous Cancer Cells through Regulating MMP-2 and MMP-9

BubR1 is a critical component of spindle assembly checkpoint, ensuring proper chromatin segregation during mitosis. Recent studies showed that BubR1 was overexpressed in many cancer cells, including oral squamous cell carcinomas (OSCC). However, the effect of BubR1 on metastasis of OSCC remains uncl...

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Bibliographic Details
Main Authors: Chou-Kit Chou, Chang-Yi Wu, Jeff Yi-Fu Chen, Ming-Chong Ng, Hui-Min David Wang, Jen-Hao Chen, Shyng-Shiou F. Yuan, Eing-Mei Tsai, Jan-Gowth Chang, Chien-Chih Chiu
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:International Journal of Molecular Sciences
Subjects:
BubR1
spindle assembly checkpoint
oral squamous cancer cell
migration
metastasis
Online Access:http://www.mdpi.com/1422-0067/16/7/15104

Internet

http://www.mdpi.com/1422-0067/16/7/15104

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