Methotrexate Associated Renal Impairment Is Related to Delayed Elimination of High-Dose Methotrexate
Although Methotrexate (MTX) is an effective drug for the treatment of acute lymphoblastic leukemia (ALL), the toxicity remains a significant problem. In this prospective study, fifty-four patients with ALL were enrolled. 3 g or 5 g MTX/m2 was administered over 24 hours. Serum MTX concentrations were...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2015-01-01
|
Series: | The Scientific World Journal |
Online Access: | http://dx.doi.org/10.1155/2015/751703 |