STAT3 modulates reprogramming efficiency of human somatic cells; insights from autosomal dominant Hyper IgE syndrome caused by STAT3 mutations

STAT3 modulates reprogramming efficiency of human somatic cells; insights from autosomal dominant Hyper IgE syndrome caused by STAT3 mutations

Human induced pluripotent stem cell (iPSC) technology has opened exciting opportunities for stem-cell-based therapy. However, its wide adoption is precluded by several challenges including low reprogramming efficiency and potential for malignant transformation. Better understanding of the molecular...

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Bibliographic Details
Main Authors: Zhen Yu, Natalia I. Dmitrieva, Avram D. Walts, Hui Jin, Yangtengyu Liu, Xianfeng Ping, Elisa A. Ferrante, Lugui Qiu, Steven M. Holland, Alexandra F. Freeman, Guibin Chen, Manfred Boehm
Format: Article
Language:English
Published: The Company of Biologists 2020-09-01
Series:Biology Open
Subjects:
reprogramming
stat3
hyper ige syndrome
ipsc
Online Access:http://bio.biologists.org/content/9/9/bio052662

Internet

http://bio.biologists.org/content/9/9/bio052662

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