Increasing Oxygen Partial Pressures Induce a Distinct Transcriptional Response in Human PBMC: A Pilot Study on the “Normobaric Oxygen Paradox”

Increasing Oxygen Partial Pressures Induce a Distinct Transcriptional Response in Human PBMC: A Pilot Study on the “Normobaric Oxygen Paradox”

The term “normobaric oxygen paradox” (NOP), describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as oxygen shortage, and resulting in up-regulation of the Hypoxia-inducible factor 1α (HIF-1α) transcription factor activity. The molecular characteristics of this...

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Bibliographic Details
Main Authors: Deborah Fratantonio, Fabio Virgili, Alessandro Zucchi, Kate Lambrechts, Tiziana Latronico, Pierre Lafère, Peter Germonpré, Costantino Balestra
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
pulsed hyperoxia
HIF-1α
NRF2
NF-kB
hyperbaric oxygen
relative hypoxia
Online Access:https://www.mdpi.com/1422-0067/22/1/458

Internet

https://www.mdpi.com/1422-0067/22/1/458

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