The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients

The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients

Autoantibodies to myelin oligodendrocytes glycoprotein (MOG) are found in a fraction of patients with inflammatory demyelination and are detected with MOG-transfected cells. While the prototype anti-MOG mAb 8-18C5 and polyclonal anti-MOG responses from different mouse strains largely recognize the F...

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Bibliographic Details
Main Authors: Iris Marti Fernandez, Caterina Macrini, Markus Krumbholz, Paul J. Hensbergen, Agnes L. Hipgrave Ederveen, Stephan Winklmeier, Atay Vural, Asli Kurne, Dieter Jenne, Frits Kamp, Lisa Ann Gerdes, Reinhard Hohlfeld, Manfred Wuhrer, Tania Kümpfel, Edgar Meinl
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
myelin oligodendrocyte glycoprotein (MOG)
glycosylation
autoantibody recognition
mass-spectrometry
demyelination
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01189/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01189/full

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