Statin Therapy and the Development of Cerebral Amyloid Angiopathy—A Rodent in Vivo Approach

Statin Therapy and the Development of Cerebral Amyloid Angiopathy—A Rodent in Vivo Approach

Background: Cerebral amyloid angiopathy (CAA) is characterized by vascular deposition of amyloid β (Aβ) with a higher incidence of cerebral microbleeds (cMBs) and spontaneous hemorrhage. Since statins are known for their benefit in vascular disease we tested for the effect on CAA. Methods: APP23-tra...

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Bibliographic Details
Main Authors: Björn Reuter, Alexander Venus, Saskia Grudzenski, Patrick Heiler, Lothar Schad, Matthias Staufenbiel, Michael G. Hennerici, Marc Fatar
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:International Journal of Molecular Sciences
Subjects:
CAA
transgenic mice
APP23
statins
cerebral microbleeds
amyloid
Online Access:http://www.mdpi.com/1422-0067/17/1/126

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http://www.mdpi.com/1422-0067/17/1/126

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