Balancing sensitivity and specificity in distinguishing TCR groups by CDR sequence similarity

Balancing sensitivity and specificity in distinguishing TCR groups by CDR sequence similarity

Abstract Background Repertoire sequencing is enabling deep explorations into the cellular immune response, including the characterization of commonalities and differences among T cell receptor (TCR) repertoires from different individuals, pathologies, and antigen specificities. In seeking to underst...

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Bibliographic Details
Main Authors: Neerja Thakkar, Chris Bailey-Kellogg
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Bioinformatics
Subjects:
Antigen-specific recognition
CDR classification
Immune repertoire
Sequence similarity
T cell receptor
Online Access:http://link.springer.com/article/10.1186/s12859-019-2864-8

Internet

http://link.springer.com/article/10.1186/s12859-019-2864-8

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