Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer

Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer

Abstract Background Although chemotherapy represents a predominant anti-cancer therapeutic modality, drug treatment efficacy is often limited due to the development of resistant tumor cells. The pregnane X receptor (PXR) affects chemotherapeutic effects by regulating targets involved in drug metabol...

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Bibliographic Details
Main Authors: Yan Dong, Zhe Wang, Gan-feng Xie, Chong Li, Wen-wei Zuo, Gang Meng, Cheng-ping Xu, Jian-jun Li
Format: Article
Language:English
Published: BMC 2017-03-01
Series:Molecular Cancer
Subjects:
Colorectal cancer
Chemotherapy resistance
PXR
MRP3
Transcriptional regulation
Overall survival
Online Access:http://link.springer.com/article/10.1186/s12943-017-0641-8

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http://link.springer.com/article/10.1186/s12943-017-0641-8

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