Engineered niches support the development of human dendritic cells in humanized mice

Engineered niches support the development of human dendritic cells in humanized mice

Classical human dendritic cells (cDCs) are rare sentinel cells specialized in regulating adaptive immunity. Here, the authors show that expression of membrane bound FLT3L, along with stem cell factor (SCF) and CXCL12 in stromal cells induces specification of pre/AS-DCs, type 1 and type2 cDC from hae...

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Bibliographic Details
Main Authors: Giorgio Anselmi, Kristine Vaivode, Charles-Antoine Dutertre, Pierre Bourdely, Yoann Missolo-Koussou, Evan Newell, Oliver Hickman, Kristie Wood, Alka Saxena, Julie Helft, Florent Ginhoux, Pierre Guermonprez
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15937-y

Internet

https://doi.org/10.1038/s41467-020-15937-y

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