Anti-Leishmanial and Immunomodulatory Effects of Epigallocatechin 3-O-Gallate on Leishmania tropica: Apoptosis and Gene Expression Profiling

Anti-Leishmanial and Immunomodulatory Effects of Epigallocatechin 3-O-Gallate on Leishmania tropica: Apoptosis and Gene Expression Profiling

Background: Pentavalent antimonials such as meglumine antimoniate (MA, Glucantime), are the first-line treatment against leishmaniasis, but at present, they have basically lost their efficacy. This study was aimed to explore epigallocatechin 3-O-gallate (EGCG), alone or in combination with MA again...

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Main Authors: Morteza SADUQI, Iraj SHARIFI, Zahra BABAEI, Alireza KEYHANI, Mahshid MOSTAFAVI, Maryam HAKIMI PARIZI, Mahdiyeh GHASEMIAN, Mehdi BAMOROVAT, Fatemeh SHARIFI, Mohammad Reza AFLATOONIAN, Fariba SHARIFIFAR, Pooya GHASEMI NEJAD, Ahmad KHOSRAVI, Ehsan SALARKIA, Rajender S. VARMA
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2019-12-01
Series:Iranian Journal of Parasitology
Subjects:
Epigallocatechin 3-O-gallate
Leishmania tropica
Immunomodulatory role
Apoptosis
Gene expression
Online Access:https://ijpa.tums.ac.ir/index.php/ijpa/article/view/2268

Internet

https://ijpa.tums.ac.ir/index.php/ijpa/article/view/2268

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