The effect of age on thymic function

Age-related regression of the thymus is associated with a decline in naïve T cell output. This is thought to contribute to the reduction in T cell diversity seen in older individuals and linked with increased susceptibility to infection, autoimmune disease and cancer. Thymic involution is...

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Bibliographic Details
Main Author: Donald B. Palmer
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00316/full