Comparison of Sirtuin 3 Levels in ALS and Huntington’s Disease—Differential Effects in Human Tissue Samples vs. Transgenic Mouse Models

Comparison of Sirtuin 3 Levels in ALS and Huntington’s Disease—Differential Effects in Human Tissue Samples vs. Transgenic Mouse Models

Neurodegenerative diseases are characterized by distinct patterns of neuronal loss. In amyotrophic lateral sclerosis (ALS) upper and lower motoneurons degenerate whereas in Huntington’s disease (HD) medium spiny neurons in the striatum are preferentially affected. Despite these differences the patho...

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Bibliographic Details
Main Authors: Eva Buck, Hanna Bayer, Katrin S. Lindenberg, Johannes Hanselmann, Noemi Pasquarelli, Albert C. Ludolph, Patrick Weydt, Anke Witting
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
amyotrophic lateral sclerosis
Huntington’s disease
Sirt3
PGC-1α
mitochondria
SOD(G93A)
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00156/full

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http://journal.frontiersin.org/article/10.3389/fnmol.2017.00156/full

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