Mitochondrial Fission and Mitophagy Coordinately Restrict High Glucose Toxicity in Cardiomyocytes

Mitochondrial Fission and Mitophagy Coordinately Restrict High Glucose Toxicity in Cardiomyocytes

Hyperglycemia-induced mitochondrial dysfunction plays a key role in the pathogenesis of diabetic cardiomyopathy. Injured mitochondrial segments are separated by mitochondrial fission and eliminated by autophagic sequestration and subsequent degradation in the lysosome, a process termed mitophagy. Ho...

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Bibliographic Details
Main Authors: Satoru Kobayashi, Fengyi Zhao, Ziying Zhang, Tamayo Kobayashi, Yuan Huang, Bingyin Shi, Weihua Wu, Qiangrong Liang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Physiology
Subjects:
diabetes
hyperglycemia
cardiomyocytes
mitochondrial fission
mitophagy
Parkin
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.604069/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.604069/full

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