ETS1 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cells.

ETS1 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cells.

EGFR-MEK-ERK signaling pathway has an established role in promoting malignant growth and disease progression in human cancers. Therefore identification of transcriptional targets mediating the oncogenic effects of the EGFR-MEK-ERK pathway would be highly relevant. Cancerous inhibitor of protein phos...

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Bibliographic Details
Main Authors: Anchit Khanna, Juha Okkeri, Turker Bilgen, Timo Tiirikka, Mauno Vihinen, Tapio Visakorpi, Jukka Westermarck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3062549?pdf=render

Internet

http://europepmc.org/articles/PMC3062549?pdf=render

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