JmjC-KDMs KDM3A and KDM6B modulate radioresistance under hypoxic conditions in esophageal squamous cell carcinoma

JmjC-KDMs KDM3A and KDM6B modulate radioresistance under hypoxic conditions in esophageal squamous cell carcinoma

Abstract Esophageal squamous cell carcinoma (ESCC), the most frequent esophageal cancer (EC) subtype, entails dismal prognosis. Hypoxia, a common feature of advanced ESCC, is involved in resistance to radiotherapy (RT). RT response in hypoxia might be modulated through epigenetic mechanisms, constit...

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Bibliographic Details
Main Authors: Catarina Macedo-Silva, Vera Miranda-Gonçalves, Ana Lameirinhas, Joana Lencart, Alexandre Pereira, João Lobo, Rita Guimarães, Ana Teresa Martins, Rui Henrique, Isabel Bravo, Carmen Jerónimo
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-020-03279-y

Internet

https://doi.org/10.1038/s41419-020-03279-y

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