PML nuclear bodies and neuronal intranuclear inclusion in polyglutamine diseases

PML nuclear bodies and neuronal intranuclear inclusion in polyglutamine diseases

In polyglutamine diseases, accumulation in the nucleus of mutant proteins induces the formation of neuronal intranuclear inclusions (NIIs). The nucleus is compartmentalized into structural and functional domains, which are involved in NII formation. Promyelocytic leukemia protein (PML), a major comp...

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Bibliographic Details
Main Authors: Junko Takahashi, Hiroto Fujigasaki, Kiyoshi Iwabuchi, Amalia C Bruni, Toshiki Uchihara, Khalid H El Hachimi, Giovanni Stevanin, Alexandra Dürr, Anne-Sophie Lebre, Yvon Trottier, Hugues de Thé, Junichi Tanaka, Jean-Jacques Hauw, Charles Duyckaerts, Alexis Brice
Format: Article
Language:English
Published: Elsevier 2003-08-01
Series:Neurobiology of Disease
Subjects:
Polyglutamine diseases
Neuronal intranuclear inclusions
Nuclear bodies
Promyelocytic leukemia protein
mSin3A
Ubiquitin
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103000809

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http://www.sciencedirect.com/science/article/pii/S0969996103000809

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