PGI<sub>2</sub> Analog Attenuates Salt-Induced Renal Injury through the Inhibition of Inflammation and Rac1-MR Activation

PGI<sub>2</sub> Analog Attenuates Salt-Induced Renal Injury through the Inhibition of Inflammation and Rac1-MR Activation

Renal inflammation is known to be involved in salt-induced renal damage, leading to end-stage renal disease. This study aims to evaluate the role of inflammation in anti-inflammatory and renoprotective effects of beraprost sodium (BPS), a prostaglandin I<sub>2</sub> (PGI<sub>2</...

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Bibliographic Details
Main Authors: Daigoro Hirohama, Wakako Kawarazaki, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Takeshi Marumo, Shigeru Shibata, Toshiro Fujita
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
blood pressure
inflammation
mineralocorticoid receptor
Rac1
renal injury
salt-sensitive hypertension
Online Access:https://www.mdpi.com/1422-0067/21/12/4433

Internet

https://www.mdpi.com/1422-0067/21/12/4433

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