AGO2 Negatively Regulates Type I Interferon Signaling Pathway by Competition Binding IRF3 with CBP/p300

AGO2 Negatively Regulates Type I Interferon Signaling Pathway by Competition Binding IRF3 with CBP/p300

Viral infection triggers a series of signaling cascades and host innate immune responses, including interferon (IFN) production, which depends on coordinated activity of multiple transcription factors. IFN regulatory factor 3 (IRF3) and transcriptional coactivator CREB binding protein (CBP) and/or p...

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Bibliographic Details
Main Authors: Shengyu Wang, Xin Sun, Chenyang Yi, Dan Zhang, Xian Lin, Xiaomei Sun, Huanchun Chen, Meilin Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
AGO2
negative regulation
type I interferon
IRF3
CBP/p300
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00195/full

Internet

http://journal.frontiersin.org/article/10.3389/fcimb.2017.00195/full

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