PINK1 positively regulates IL-1β-mediated signaling through Tollip and IRAK1 modulation

PINK1 positively regulates IL-1β-mediated signaling through Tollip and IRAK1 modulation

<p>Abstract</p> <p>Background</p> <p>Parkinson disease (PD) is characterized by a slow, progressive degeneration of dopaminergic neurons in the substantianigra. The cause of neuronal loss in PD is not well understood, but several genetic loci, including PTEN-induced put...

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Bibliographic Details
Main Authors: Lee Hyun Jung, Chung Kwang Chul
Format: Article
Language:English
Published: BMC 2012-12-01
Series:Journal of Neuroinflammation
Subjects:
IL-1β
Inflammation
Parkinson disease
PTEN-induced putative kinase 1
Toll-interacting protein
IL-1 receptor-associated kinase 1
Online Access:http://www.jneuroinflammation.com/content/9/1/271

Internet

http://www.jneuroinflammation.com/content/9/1/271

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