An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer

An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer

Alternative splicing of mRNA precursors represents a key gene expression regulatory step and permits the generation of distinct protein products with diverse functions. In a genome-scale expression screen for inducers of the epithelial-to-mesenchymal transition (EMT), we found a striking enrichment...

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Bibliographic Details
Main Authors: Ji Li, Peter S Choi, Christine L Chaffer, Katherine Labella, Justin H Hwang, Andrew O Giacomelli, Jong Wook Kim, Nina Ilic, John G Doench, Seav Huong Ly, Chao Dai, Kimberly Hagel, Andrew L Hong, Ole Gjoerup, Shom Goel, Jennifer Y Ge, David E Root, Jean J Zhao, Angela N Brooks, Robert A Weinberg, William C Hahn
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
alternative splicing
QKI
RBFOX1
FLNB
EMT
basal-like breast cancer
Online Access:https://elifesciences.org/articles/37184

Internet

https://elifesciences.org/articles/37184

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