Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers

Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers

Abstract Broadly neutralizing antibodies (bnAbs) against HIV-1 protect from infection and reduce viral load upon therapeutic applications. However no vaccine was able so far to induce bnAbs demanding their expensive biotechnological production. For clinical applications, nanobodies (VHH) derived fro...

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Bibliographic Details
Main Authors: Kathrin Koch, Sarah Kalusche, Jonathan L. Torres, Robyn L. Stanfield, Welbeck Danquah, Kamal Khazanehdari, Hagen von Briesen, Eric R. Geertsma, Ian A. Wilson, Ulrich Wernery, Friedrich Koch-Nolte, Andrew B. Ward, Ursula Dietrich
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08273-7

Internet

https://doi.org/10.1038/s41598-017-08273-7

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