Medullary Thymic Epithelial Cells and Central Tolerance in Autoimmune Hepatitis Development: Novel Perspective from a New Mouse Model

Medullary Thymic Epithelial Cells and Central Tolerance in Autoimmune Hepatitis Development: Novel Perspective from a New Mouse Model

Autoimmune hepatitis (AIH) is an immune-mediated disorder that affects the liver parenchyma. Diagnosis usually occurs at the later stages of the disease, complicating efforts towards understanding the causes of disease development. While animal models are useful for studying the etiology of autoimmu...

Full description

Bibliographic Details
Main Authors: Konstantina Alexandropoulos, Anthony J. Bonito, Erica G. Weinstein, Olivier Herbin
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:International Journal of Molecular Sciences
Subjects:
autoimmune hepatitis (AIH)
T-cells
medullary thymic epithelial cells
medullary thymic epithelial cells (mTECs)
central tolerance
peripheral tolerance
autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)
autoimmune polyendocrine syndrome (APS)
regulatory T-cells
soluble liver antigen
antinuclear antibodies
Online Access:http://www.mdpi.com/1422-0067/16/1/1980

Internet

http://www.mdpi.com/1422-0067/16/1/1980

Similar Items