Lineage reprogramming of fibroblasts into induced cardiac progenitor cells by CRISPR/Cas9-based transcriptional activators

Lineage reprogramming of fibroblasts into induced cardiac progenitor cells by CRISPR/Cas9-based transcriptional activators

Overexpression of exogenous lineage-determining factors succeeds in directly reprogramming fibroblasts to various cell types. Several studies have reported reprogramming of fibroblasts into induced cardiac progenitor cells (iCPCs). CRISPR/Cas9-mediated gene activation is a potential approach for cel...

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Bibliographic Details
Main Authors: Jianglin Wang, Xueyan Jiang, Lixin Zhao, Shengjia Zuo, Xiantong Chen, Lingmin Zhang, Zhongxiao Lin, Xiaoya Zhao, Yuyan Qin, Xinke Zhou, Xi-Yong Yu
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Acta Pharmaceutica Sinica B
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383519305969

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http://www.sciencedirect.com/science/article/pii/S2211383519305969

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