Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software

How gene regulatory pathways control cell fate decisions in single cells is not fully understood. Here the authors present an integrated dual-input microfluidic chip and a linked analysis software, enabling tracking of gene regulatory responses of single bacterial cells to changing conditions.

Bibliographic Details
Main Authors:	Matthias Kaiser, Florian Jug, Thomas Julou, Siddharth Deshpande, Thomas Pfohl, Olin K. Silander, Gene Myers, Erik van Nimwegen
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02505-0

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spelling	doaj-066a24f172fb44468bc65e725b60b53d2021-05-11T09:24:51ZengNature Publishing GroupNature Communications2041-17232018-01-019111610.1038/s41467-017-02505-0Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and softwareMatthias Kaiser0Florian Jug1Thomas Julou2Siddharth Deshpande3Thomas Pfohl4Olin K. Silander5Gene Myers6Erik van Nimwegen7Biozentrum, University of Basel and Swiss Institute of BioinformaticsMax Planck Institute of Molecular Cell Biology and GeneticsBiozentrum, University of Basel and Swiss Institute of BioinformaticsDepartment of Chemistry, University of BaselDepartment of Chemistry, University of BaselBiozentrum, University of Basel and Swiss Institute of BioinformaticsMax Planck Institute of Molecular Cell Biology and GeneticsBiozentrum, University of Basel and Swiss Institute of BioinformaticsHow gene regulatory pathways control cell fate decisions in single cells is not fully understood. Here the authors present an integrated dual-input microfluidic chip and a linked analysis software, enabling tracking of gene regulatory responses of single bacterial cells to changing conditions.https://doi.org/10.1038/s41467-017-02505-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Matthias Kaiser Florian Jug Thomas Julou Siddharth Deshpande Thomas Pfohl Olin K. Silander Gene Myers Erik van Nimwegen
spellingShingle	Matthias Kaiser Florian Jug Thomas Julou Siddharth Deshpande Thomas Pfohl Olin K. Silander Gene Myers Erik van Nimwegen Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software Nature Communications
author_facet	Matthias Kaiser Florian Jug Thomas Julou Siddharth Deshpande Thomas Pfohl Olin K. Silander Gene Myers Erik van Nimwegen
author_sort	Matthias Kaiser
title	Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software
title_short	Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software
title_full	Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software
title_fullStr	Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software
title_full_unstemmed	Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software
title_sort	monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-01-01
description	How gene regulatory pathways control cell fate decisions in single cells is not fully understood. Here the authors present an integrated dual-input microfluidic chip and a linked analysis software, enabling tracking of gene regulatory responses of single bacterial cells to changing conditions.
url	https://doi.org/10.1038/s41467-017-02505-0
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Monitoring single-cell gene regulation under dynamically controllable conditions with integrated microfluidics and software

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