Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection.

Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection.

Effector responses induced by polarized CD4+ T helper 2 (Th2) cells drive nonhealing responses in BALB/c mice infected with Leishmania major. Th2 cytokines IL-4 and IL-13 are known susceptibility factors for L. major infection in BALB/c mice and induce their biological functions through a common rec...

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Bibliographic Details
Main Authors: Magdalena Radwanska, Antony J Cutler, J Claire Hoving, Stefan Magez, Christoph Holscher, Andreas Bohms, Berenice Arendse, Richard Kirsch, Thomas Hunig, James Alexander, Paul Kaye, Frank Brombacher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.0030068

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https://doi.org/10.1371/journal.ppat.0030068

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