A role for PCNA ubiquitination in immunoglobulin hypermutation.
Proliferating cell nuclear antigen (PCNA) is a DNA polymerase cofactor and regulator of replication-linked functions. Upon DNA damage, yeast and vertebrate PCNA is modified at the conserved lysine K164 by ubiquitin, which mediates error-prone replication across lesions via translesion polymerases. W...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-11-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC1618868?pdf=render |