GSK-3β Contributes to Parkinsonian Dopaminergic Neuron Death: Evidence From Conditional Knockout Mice and Tideglusib

GSK-3β Contributes to Parkinsonian Dopaminergic Neuron Death: Evidence From Conditional Knockout Mice and Tideglusib

Glycogen synthase kinase-3 (GSK-3) dysregulation has been implicated in nigral dopaminergic neurodegeneration, one of the main pathological features of Parkinson’s disease (PD). The two isoforms, GSK-3α and GSK-3β, have both been suggested to play a detrimental role in neuronal death. To date, sever...

Full description

Bibliographic Details
Main Authors: Junyu Li, Shanshan Ma, Jingnan Chen, Kunhua Hu, Yongyi Li, Zeyu Zhang, Zixiang Su, James R. Woodgett, Mingtao Li, Qiaoying Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Parkinson’s disease
GSK-3β
GSK-3α
tideglusib
neuroprotection
MPTP
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00081/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2020.00081/full

Similar Items