TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis

TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis

Abnormal functions of mesenchymal stem cells (MSC) contribute into the pathogenensis of ankylosing spondylitis (AS). Here, the authors show that TNF-α at high concentration induces enhances migration of AS-MSC through METTL14 mediated m6A modification of the ELMO1 3′ UTR.

Bibliographic Details
Main Authors: Zhongyu Xie, Wenhui Yu, Guan Zheng, Jinteng Li, Shuizhong Cen, Guiwen Ye, Zhaofeng Li, Wenjie Liu, Ming Li, Jiajie Lin, Zepeng Su, Yunshu Che, Feng Ye, Peng Wang, Yanfeng Wu, Huiyong Shen
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25710-4

Internet

https://doi.org/10.1038/s41467-021-25710-4

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